21 January 2022

WHO recommends two new drugs to treat patients with COVID-19  

 

The World Health Organization (WHO) recommended two new drugs to treat patients with COVID-19, one for patients with critical disease, and the other deemed effective for non-severe cases. For both, the effectiveness against new variants, like Omicron, is still uncertain. The recommendations are based on new evidence from seven trials involving over 4,000 patients with non-severe, severe, and critical infections.

Severe cases

The first drug, baricitinib, is a Janus kinase (JAK) inhibitor - a class of drugs used to treat autoimmune conditions, blood and bone marrow cancers, and rheumatoid arthritis.

According to the WHO Guideline Development Group, it is “strongly recommended” for patients with severe or critical disease in combination with corticosteroids.

The group of international experts based their recommendation on “moderate certainty evidence” that it improves survival and reduces the need for ventilation.

There was no observed increase in adverse effects.

The experts note that it has a similar effect as other arthritis drugs called interleukin-6 (IL-6) inhibitors. Because of that, when both drugs are available, they suggest choosing the best option based on cost, availability, and clinician experience. But it is not recommended to use both drugs at the same time.

Non-severe cases

WHO makes a conditional recommendation for the use of a monoclonal antibody known as sotrovimab in patients with non-severe cases. The drug should only be administered to patients at the highest risk of hospitalisation. In those at lower risk, it only showed “trivial benefits”.

A similar recommendation has been made previously, for another monoclonal antibody drug, casirivimab-imdevimab, and the experts say there is insufficient data to recommend one over the other.

16 January 2022

Is Chocolate Milk Good For You?

After a hard workout, chocolate milk can provide you with the fluid and nutrients needed to support recovery.

What chocolate milk has going for it is that its composition is naturally in line with the fluid, macro and micronutrients needed to support exercise recovery. For a 2017 review published in the European Journal of Clinical Nutrition, researchers concluded that chocolate milk seems to be a good candidate to aid recovery because it contains nutrients needed for replenishment and healing.

Athletes who drank chocolate milk took longer to reach exhaustion, leading researchers to conclude that the beverage is an effective recovery aid between two fatiguing bouts of exercise. 

A more recent study looked at chocolate milk vs water as recovery aids following all-out bouts of high-intensity endurance climbing. When consumed chocolate milk, men could improve their performance in terms of distance climbed and duration of the workout. Muscle soreness scores were also lower three days after exercise for the chocolate milk drinkers. 

Chocolate milk is available in the forms of whole (3.5% fat by weight), 2%, 1%, and skim. While chocolate milk provides some key nutrients such as fat, carbohydrate, protein, calcium, the B vitamin riboflavin, potassium, vitamins A and D, it also delivers a third of the recommended maximum daily intake of added sugar for women, based on guidelines from the American Heart Association.

Although chocolate milk can support exercise recovery and it is relatively available and affordable, it is not the only choice—and it is also not an option at all for certain people, including those with a milk allergy or sensitivity, people with lactose intolerance and vegans. It is also not the only source of recovery nutrients.

If dairy-based chocolate milk is not a good option for you for whatever reason, or you simply choose not to drink it, there are plenty of other alternatives. One is chocolate plant milk made from split peas. Like dairy-based chocolate milk, chocolate pea milk provides 8 grams of protein per cup and is also a good source of leucine.

If you reach for chocolate milk occasionally as a treat, it may provide more nutrients than other sweet option it displaces, such as ice cream or a brownie.

14 January 2022

EWG Releases 2021 “Dirty Dozen” and “Clean Fifteen” Lists


The Environmental Working Group (EWG) released its 2021 “Dirty Dozen” and “Clean Fifteen” lists — a catalog of conventionally grown fruits and vegetables with the highest and lowest amounts of pesticide residue. 

More than 90 percent of produce sampled, including strawberries, apples, cherries, spinach, nectarines, and leafy greens, tested positive for two or more pesticides. 

This year’s study revealed that strawberries topped the “Dirty Dozen” list for the fifth year in row while leafy greens are among the most contaminated produce. A single sample of conventional kale, collard greens and mustard greens was found to contain 20 different pesticides. 

The study also found a number of harmful fungicides in citrus fruits. The fungicide imazalil, for example, was detected on nearly 90 percent of EWG-sampled citrus. The fungicide disrupts the endocrine system and is recognized by the EPA as a likely carcinogen. Of the conventional citrus fruits tested by EWG, mandarins, followed by oranges and grapefruit, were found to have the highest levels of fungicides. 

Eating plenty of fresh produce is an essential part of daily nutrition. “Whenever possible, shoppers should opt for organic produce,” says EWG toxicologist Thomas Galligan. 

“When organic produce is not available or affordable, shoppers can use EWG’s ‘Clean Fifteen’ list to find conventional fruits and vegetables that are relatively low in pesticides.” 

The Dirty Dozen:

  • Strawberries
  • Spinach
  • Kale, collard and mustard greens
  • Nectarines
  • Apples
  • Grapes
  • Cherries
  • Peaches
  • Pears
  • Bell and hot peppers
  • Tomatoes
  • Celery

The Clean Fifteen: 

  • Avocados
  • Sweet corn
  • Pineapples
  • Onions
  • Papaya
  • Sweet peas
  • Eggplants
  • Asparagus
  • Broccoli
  • Cabbage
  • Kiwi
  • Cauliflower
  • Mushrooms
  • Honeydew melons
  • Cantaloupes

09 January 2022

WHO signals alarm about dementia challenge

 

The World Health Organisation (WHO) released its first report on the global status of the public health response to dementia, showing that only a quarter of countries worldwide have a national policy, strategy or plan for supporting people with dementia and their families. 

These gaps are increasingly concerning, as the number of people living with dementia is growing. WHO estimates that more than 55 million people (8.1% of women and 5.4% of men over 65 years) are living with dementia. As life expectancy increases worldwide, this number is estimated to rise to 78 million by 2030 and to 139 million by 2050. 

To drive change, the report highlights the urgent need to strengthen support at national level, for both people with dementia and those who care for them. Many countries lack earmarked funding in national health budgets, leaving significant gaps in treatment and care, and do not comprehensively involve people with dementia and their carers and families in developing policies. These are among the areas for change.  

WHO is also developing a Dementia Research Blueprint, to structure research efforts and stimulate new initiatives, helping to overcome challenges related to past unsuccessful clinical trials for treatments and the high costs of research and development.

04 January 2022

The Link Between Food and Mood

Serotonin is a natural chemical known for contributing to feelings of wellbeing and happiness. Your microbiome (the community of bacteria, the commensal microbiota, that colonize all mucosal sites in the body) is home to a whopping 90% of the body’s serotonin receptors, and so when your gut is functioning optimally, your mood benefits. If your gut is feeling depleted or unbalanced, your serotonin levels will likely be low as well. The foods you eat directly impact how your microbiome works on a daily basis.

But that is not all. How frequently you eat directly impacts your blood sugar levels. Keeping your blood sugar levels as consistent as possible can contribute to a more positive mood. According to research, eating regular meals and snacks at the same times every day can help keep your blood sugar levels steady as you provide your body with a continuous source of fuel.

Moreover, certain nutrients within the foods can help lift your mood and keep stress at bay.

Nutrient-rich protein sources like eggs, poultry, seafood and soy can help slow the rate at which your digestive system processes carbohydrates, preventing your blood sugar from spiking dramatically. Your gut also releases more dopamine, another feel-good hormone, as it breaks down protein.

Probiotic foods like yogurt, kefir, kombucha and sauerkraut keep the good bacteria in your gut flourishing while minimizing the bacteria that does not serve you. This leads to a balanced, happy tummy that is ready to keep those serotonin receptors firing.

Prebiotic (fiber-rich) options like oats, beans, apples, pears and Brussels sprouts provide the “food” for the good bacteria in your gut to feast on, keeping them alive and well so they can do their job to balance your microbiome.

Foods rich in folate and vitamin B-12 can also help to boost your mood. And since B-12 is better absorbed by your body when it is consumed alongside folate, certain food pairings are more impactful than others. Put a folate-rich food like broccoli, lentils, dark leafy greens or oranges on your plate next to a food full of B-12 like cottage cheese, lean beef or salmon, and you will be in good shape.

Foods rich in vitamin D are known to help with your mood as well. Thus low-fat milk, egg yolks and soy milk can be great additions to your diet.

Omega-3 fatty acids from salmon, tuna, flaxseed, chia seeds and walnuts can help boost your mood, reduce anxiousness and increase your ability to handle stress.

Foods full of magnesium like dark chocolate, avocado, nuts, legumes and tofu can help you manage anxiety. When you become stressed, your body actually uses more magnesium, so you need even more.

On the flip side, if you are looking to avoid mood swings and drops in energy throughout the day, try to avoid the following foods when possible:

Refined white starches like white rice, white bread and crackers can lead to major spikes in blood sugar followed by big crashes, which zap your good mood. Thus if you eat white rice, pair it with a lean protein source and healthy fat to prevent the pitfall, and opt for more complex, whole grain and multigrain breads instead of white varieties to help balance your blood sugar.

Simple sugars can also create dramatic ebbs and flows in your blood sugar levels. While they are present in junk foods like candy and soda, they also exist in everyday foods like fruit juice and jams, so be mindful to pair these options with a healthy fat or protein to balance how quickly your body digests the meal. Look for healthier sugar alternatives instead.

Alcohol is a depressant and also a major sleep disruptor, which will further impact your mood—and not in a good way—especially if you overdo it and consume it close to bedtime.

Ultra-processed foods that contain chemical additives can destroy the good bacteria in your gut, creating an imbalance that ultimately impacts your mood in a negative way. So steer clear of these options and swap in whole foods instead.